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Associate Scientist

Gaithersburg, MD

Posted: 01/05/2023 Job Number: 22777792

Job Description

100% onsite.

Required Skills:
  • A BS or master's degree with an engineering discipline focused on biologics, ideally protein based recombinant purification, with a focus in a process engineering field (e.G., chemical, or biochemical engineering) is strongly preferred.
  • Industry related experience Associate Scientist I (BS with 0-5 years, MS 0-3 years) or Scientist (BS 8-12, MS 4-8); industrial experience developing or supporting clinical or commercial biotechnology is not required.
  • Buffer formulation, lab equipment operation such as AKTA Avant, peristaltic pumps, pressure sensors, pH probes, pipet operation, UV spectrophotometry.
  • Experimental design with proteins.
  • Theory of Protein ion exchange and affinity chromatography or affinity precipitation.
  • Fundamental and practical understanding of downstream unit operations.
  • Arduino programming and building prototypes.
  • Experience with GMP equipment design and use of data management systems.
  • Skilled in problem-solving.
  • Skilled in effectively explaining complex scientific or engineering concepts to a broader, diverse, cross-functional audience.

Project Description:
  • As a purification Associate Scientist in Bioprocess Technology and Engineering (BTE), you would join a team developing the Client's Next Generation Manufacturing Platform.
  • You and the team would develop the purification platform to support a high-density perfusion cell culture for biological therapeutics, including antibodies, bispecific antibodies, and Fc-fusions.
  • You would apply the Next Generation Manufacturing methods to drug candidates in Phase I, II, and those entering Phase III.
  • As the molecules progress through the development lifecycle, you will have opportunity to develop the process characterization methods to support commercialization.
  • You would work on a matrix team with members from cell line development, cell culture development, purification development, analytical development, formulation development, and data analytics and modelling.
  • You would have opportunity to operate small scale and pilot scale purification systems.
  • Your work would be used to design processes so that they can be scaled to purify 10kg-20kg per day. You would be responsible for working jointly with your upstream colleagues to link the bioreactor to the purification process.
  • You would draw upon your publication history to publish peer-reviewed articles of your work.
  • Study and develop next generation mammalian purification processes, including chromatography, filtration, ultrafiltration operations.
  • Build or use mathematical models that predict purification.
  • Be part of a team that tests new manufacturing methods at a manufacturing scale.
  • Develop automation methods that control the entire manufacturing process.

This 6+ month position starts ASAP.

Please E-MAIL your resume (attachment to email) with rate and availability to Eric: EricCorpuz@alphaconsulting.Com


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