The candidate will work with our translational development team and independently contribute to the development and execution of laboratory experiments to understand disease biology, drug resistance, mechanism of action of drugs and drug combinations.
This will include working with lymphoma and multiple myeloma cell lines.
The candidate should have enthusiasm for helping support laboratory programs, have knowledge of cell biology, epigenetics and signal transduction pathways and technical expertise in molecular and cellular based assays documented by relevant publications and work experience.
They should also possess a strong understanding of the science behind ongoing experiments: the rationale, purpose, and appropriate analytical methods to aid experimental design, troubleshooting and result interpretation.
The candidate will provide laboratory support by means of data generation and analysis for clinical trial biomarker strategies, publications, and internal study reports.
Characterize and validate therapeutic targets identified from cancer genome project.
Performing in vitro testing of compounds to evaluate mechanisms of drug response and resistance. Developing rational drug combination strategies.
Interrogate mechanisms of drug action, drug resistance and drug synergistic effects with epigenetic approaches.
Propose and test the association between genetic features and drug resistance. Translate the results of pre-clinical studies to patient segment selection.
Detail-oriented. Keeping good experimental records. Being able to write detailed protocols.
Participating in translational team meetings by presenting data and providing interpretation of experimental results.
Helping to cultivate a positive and productive working relationship with colleagues.
Ph.D. In cellular or molecular biology, cancer biology, biochemistry, genetics, or related fields, or a master's degree in a related fields with a minimum of four years of related research experience.
Extensive knowledge about cancer biology, signal transduction and cancer epigenetics.
Expertise in general skills of molecular cell biology, such as molecular cloning, primer design, RNA isolation, RT-PCR, Western Blotting, Co-immunoprecipitation (Co-IP) and basic cellular assays (e.G., proliferation/apoptosis).
Experience with PowerPoint, FlowJo and GraphPad Prism software.
Experience with C-bioportal, DepMap and UCSC genome browser interfaces is a plus.
Communication and writing skills necessary to effectively convey data and interpretations with internal groups and at external meetings.
Problem solving skills to resolve technical issues.
Ability to manage time efficiently to meet project team deadlines and exhibit flexibility and adaptability to changing projects, work assignments and priorities.
Proficient with techniques used for epigenetic/transcriptional profiling including ChIP-seq, ATAC-seq, bulk RNA-seq and library preparation is a plus.
Experience with various genetic manipulation approaches including shRNA, RNAi, ectopic expression, and CRISPR based techniques is a plus.
Experience with flow cytometry is a plus.
This 12+month position starts ASAP.
Please E-MAIL your resume (attachment to email) with rate and availability to Bridget: bridget@alphaconsulting.Com
ALPHA'S REQUIREMENT #23-00104
MUST BE ELIGIBLE TO WORK IN THE U.S. AS AN HOURLY W2 EMPLOYEE