Senior Scientist - Molecular and Cellular Pharmacology

San Diego, CA

Posted: 07/12/2022 Job Number: 21099683

Job Description

SENIOR SCIENTIST MOLECULAR AND CELLULAR PHARMACOLOGY
SAN DIEGO, CA
Project Description:
  • The Molecular and Cellular Pharmacology Group in Oncology TRC focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation.
  • We are seeking a motivated Associate Scientist with experience in drug discovery and in vitro pharmacology to participate in research focused on protein homeostasis for cancer therapeutics.
  • The successful candidate will work collaboratively in a multi-disciplinary environment to use cell-based assays in support of discovery of small molecules as development candidates (DCs) for clinical, design and execute in vitro studies to further our understanding of the mechanisms of novel compounds.
  • The Oncology TRC is one of the fundamental research and early development engines delivering therapeutics to patients.
  • The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability.
  • This thematic focus allows the group to capitalize on the cutting-edge science that underpins the action of the company's most advanced drugs.
  • Not being bound by disease area or therapeutic modality creates a very dynamic, exciting, and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology, and translational development.
  • Develop and implement relevant cell-based and biochemical assays as well as cell models to support identification, optimization, and characterization of novel chemical matter.
  • Design and conduct critical experiments using expertise in cell biology, molecular biology, biochemistry, and assay development to support molecular mechanism of action of the drugs.
  • Analyze and present data in an organized and timely manner.
  • Support biology needs for different projects and drug discovery teams.
Required Skills:
  • Bachelor's degree in a scientific discipline with at least 4 years of work experience or Master's degree with at least 2 years of preferred experience in industry or drug discovery setting.
  • Experience in small molecule drug discovery process in an industrial setting. Understand key aspects of SAR support using biological assays.
  • Familiarity and willingness to learn in vitro cell-based assays, including but not limited to cell proliferation assays, cell cycle assay, apoptosis assay, bDNA assay, image-based assays, ELISA, and Incucyte.
  • Sophisticated experience in cell biology including mammalian cell culture, lentivirus production, transient/stable transfection, gene editing including CRISPR KO and -KI, shRNA KD.
  • Maintain cell cultures and characterize cancer cell lines, including cell proliferation/cell cycle/cell apoptosis.
  • Experience in cell biology (Transfection, Immunofluorescence, lenti-virus production), biochemistry (Western blot), molecular biology (DNA cloning, PCR, qPCR).
  • Familiar with various biology laboratory equipment with an emphasis on automation and capable of trouble shooting for SAR assay support.
  • Excellent communication, collaboration, and organizational skills.
  • Capability to stay focused, multitasked, attention to details and deliver high quality data in a timely and well-organized manner.
  • Ability to handle multiple projects and work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.

This 12+ month position starts ASAP.

Please E-MAIL your resume (attachment to email) with rate and availability to Bridget: bridget@alphaconsulting.Com

ALPHA'S REQUIREMENT #22-02118
MUST BE ELIGIBLE TO WORK IN THE U.S. AS AN HOURLY W2 EMPLOYEE

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Bridget Burns

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