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In Vivo Scientist

San Diego, CA 92121

Posted: 09/15/2023 Job Number: 24995685

Job Description


100% on site
The pay ranges between $75 to $80 per hour.
Required Skills:
  • Bachelor's Degree required.
  • 5+ years of academic and / or industry experience or master's degree.
  • 3+ years of academic and / or industry experience or Ph.D. Or equivalent advanced degree in the Life Sciences.
  • No experience necessary.
  • Proven track record in validating and implementing animal models for testing cancer therapies including xenograft and syngeneic tumor models.
  • Experience with advanced humanized models is a plus.
  • In vivo skills include animal handling, dosing of small or large molecules, ADC sample preparation, small animal surgeries, tissue sample collection, imaging modalities.
  • In vivo target validation and experience with more complex xenotransplantation, transgenic and knockout models is a plus.
  • Proficiency in laboratory bench skills such as ELISAs, Western blots, Mesoscale, qPCR, Nanostring, Flow cytometry, and/or histology is required.
  • Experience with immunophenotyping of cells from various matrices is a plus.
  • Proven track record of good experimental design, in-depth data analysis and interpretation based on strong scientific rationale.
  • Detail oriented and able to problem solve and offer potential solutions.
  • Excellent written and oral communication skills.
  • Ability to write protocols and technical reports with precision.
  • Ability to work in a fast-paced dynamic team environment.
  • Flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.
  • Supervisory experience is a plus.
  • Interface with cross-functional team members and present to multidisciplinary teams.
  • Computer skills: Advanced knowledge of Excel, Word, PowerPoint, FlowJo and GraphPad Prism.
  • Experience with StudyLog software is a plus.
  • Local candidates preferred.

Project Description:
  • The Client is seeking a motivated Scientist with a deep understanding of pharmacology in small and large molecule drug discovery processes.
  • The candidate will be expected to work collaboratively in a multi-disciplinary environment and support multiple projects.
  • The candidate will have the opportunity to lead cancer drug discovery projects, participate in the evaluation of new targets and design and implement a strategy for in vivo validation of these targets.
  • The candidate will also lead and manage the pharmacology staff assigned to him/her focusing on execution, priority setting and career development to accomplish the department and project goals.
  • The candidate will participate in the preparation of protocols and reports.
  • The candidate will work independently and be viewed as an experienced technical resource in pharmacology.
  • Independently design, plan, execute and interpret complex in vivo studies focused on identifying small and large candidate molecules and ADCs within the area of oncology.
  • Formulation of small and/or large molecules for in vivo studies.
  • Evaluation of pathway biomarkers and endpoints from in vivo studies via techniques such as flow cytometry, qPCR, IHC, ELISA, Mesoscale, Flow cytometry and Western blots.
  • Plan, execute and interpret pharmacokinetic/pharmacodynamic studies in acute and chronic disease models.
  • Data presentation to multidisciplinary discovery teams.
  • Participate in the evaluation of new targets.
  • Identification of risks within function and development of contingencies plans to mitigate risk.
  • Lead and manage the pharmacology staff assigned to them.
  • Interface with cross-functional teams and represent pharmacology on discovery teams and lead sub-teams.

This 12+ month position starts ASAP.

Please E-MAIL your resume (attachment to email) with rate and availability to Jacqueline: jacqueline@alphaconsulting.Com




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Jacqueline Sanchez

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