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Senior Research Associate

San Diego, CA 92121

Posted: 05/23/2023 Job Number: 23966312

Job Description

Pay range 47.14 to 48.88.

Project Description:
  • Our client seeks a highly motivated cell and molecular biology contractor to join our Oncology Discovery research team within the Oncogenesis Thematic Research Center (TRC) which specializes in protein homeostasis and targeted protein degradation.
  • Help develop and implement cell assays to support target identification and validation.
  • Conduct studies aimed at enhancing our comprehension of the on-target/off-target mechanisms of lead novel compounds.
  • Take responsibility for 2D/3D model and assay development.
  • The successful candidate should have strong technical skills, particularly in mammalian cell culture, CRISPR, and 3D cell models.
  • The candidate should also possess the ability to quickly learn new protocols and effectively implement changes to enhance them.
  • The candidate must be able to effectively demonstrate clear verbal and written communication skills.
  • Conduct target validation studies across a diverse range of oncology models, using CRISPR and tool compound approaches .
  • Perform organoid model development and maintenance .
  • Employ FACS and Western blots for cell analysis.
  • Perform dose-response curve experiments to assess drug efficacy .
  • Maintain and passage 2D/3D patient-derived tumor lines .
  • Perform gene editing and various molecular techniques to characterize edited cells.
  • Oversee the cryopreservation of tissues and cell lines to ensure proper storage .
  • Adhere to company regulations by meticulously maintaining precise and comprehensive laboratory notebooks and other records .
  • Write laboratory protocols and standard operating procedures in a clear and concise manner .
  • Perform a wide variety of basic molecular biology procedures .
  • Assist team members with house-keeping tasks .

Required Skills:
  • M.Sc. Degree in the biological sciences with 0-2 years of hands-on cell and molecular biology experience .
  • B.Sc. Degree with 2+ years of hands-on cell and molecular biology experience .
  • Solid hands-on experience with fundamental cell biology techniques such as:
    • Mammalian cell culture (3D culture experience is a plus) .
    • Plate-based assays such as CTG, apoptosis, Incucyte .
    • Cryopreservation .
  • Proficiency in essential molecular biology techniques such as:
    • Transfection and viral transduction techniques (overexpression, CRISPR KO) .
    • Western blotting .
    • Flow Cytometry .
  • Preference will be given to candidates with hands-on experience with 3D culture techniques .
  • Attention to detail and ability to perform delicate manual tasks in a laboratory .
  • Enthusiasm and demonstrated ability to learn and apply new laboratory techniques, skills, and instrumentations .
  • Ability to work both independently and as part of a team .
  • Strong communication skills (effectively conveying problems, protocols, and results to colleagues through clear written and verbal communication), and ability to maintain meticulous and comprehensive records .
  • Strong determination to drive projects to successful completion .
  • Able to effectively interact with colleagues of diverse backgrounds and contribute to team goals .
  • Fluency in the use of Microsoft Word, Excel, PowerPoint, and FlowJo .
  • ProteinSimple WES/JESS is a plus .

This 12+month position starts ASAP.

Please E-MAIL your resume (attachment to email) with rate and availability to Bridget: bridget@alphaconsulting.Com


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Bridget Burns

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